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KMID : 0861020110260010081
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Korea Journal of Herbology
2011 Volume.26 No. 1 p.81 ~ p.85
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Effects of Angelicae Gigantis Radix (AGR) on Polycystic Ovary induced by Estradiol Valerate in rats
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Kim Hyung-Woo
Choi Eu-Gene
Jeong Hui-Jin
Joung Young-Min
Shin Dong-Sun
Cho Su-In
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Abstract
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Objective :This study was designed to investigate the effects of Angelicae Gigantis Radix (AGR) on Polycystic Ovary (PCO) induced by Estradiol valerate (EV) in female rats.
Methods:We investigated the effects of AGR on Changes in body weights and food and water uptake for 5 weeks. In addition, we examined the effects on ovary weights. Finally, we also observed histopathological changes in PCO rats.
Results: Treatment with AGR did not affect body weights, amount of food and water uptake. Administration group of AGR restored body/ovary weight ratio to normal levels, which were lowered by induction of PCO. In histopathological observation, formation of cysts was suppressed in AGR group compared with non-treated control group.
Conclusion : These results suggest that AGR can be used for patients with PCO to prevent formation of cystic follicles and malfunction of ovary.
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KEYWORD
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Angelicae Gigantis Radix, Polycystic Ovary, cystic follicles
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